• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    The present invention relates to an extemporaneous product for the preparation of dermatological and / or cosmetic compositions, this product comprising on the one hand one or more active ingredients and on the other hand a universal base for solubilizing this active ingredient (s) and comprising at least an oil rich in omega-3, water, glycerine, another alcohol than glycerin, an emulsifier and a biomimetic peptide.
    公开号:FR3020946A1
    申请号:FR1401067
    申请日:2014-05-13
    公开日:2015-11-20
    发明作者:Charalampos Arampatzis；Claudine Masson
    申请人:UNIVERSKIN；
    IPC主号:
    专利说明:

    [0001] The technical field of the present invention is that of cosmetics and dermatology and more particularly that of cosmetic and / or dermatological compositions prepared extemporaneously. These compositions can in particular participate in the general aesthetic improvement of the skin of the body or face. The dermatologist, the aesthetic doctor and the pharmacist are confronted with very different pathologies and problems in the cutaneous domain. These include acne, allergies (eczema, urticaria), bacterial, viral and parasitic infections, psoriasis, rosacea, stretch marks, vitiligo, hair loss and seborrhea, pigmentation problems. , wrinkles and fine lines, improvement of skin texture, facial regeneration, the use of more and more invasive dermatological techniques such as peels, lasers, etc. In recent years, significant advances have been made in the study of the skin and have enabled the important development of skin evaluation and repair technologies. Despite these remarkable advances, the treatment possibilities, both in dermatology and in cosmetics, are limited to the use of products developed and formulated for a specific application and are put on the market by dermatology and cosmetic cosmetics companies. renowned. Some preparations can be prescribed by dermatologists and manufactured extemporaneously by pharmacists. However, the whole of the present care and treatment offer does not make it possible to adapt a personalized treatment adapting the various active principles, the different concentrations of these active ingredients and the synergy of successive treatments of a limited duration. 35 A strong trend is emerging in cosmetics and dermatology, that of tailored care. Patent EP-2343692 describes an apparatus for formulating customized cosmetic compositions. However, this apparatus can only be used for mixing and dispensing purely cosmetic compositions such as nail polish, mascara, etc. No diagnosis of the skin is necessary and the device works automatically. In addition, the formulations prepared according to the patent EP-2343692 require a heavy equipment. Finally, no example of composition is detailed. Pre-formulation diagnosis, linked to new evaluation technologies, is one of the ways 10 that is being put in place to offer formulas adapted to the skin of everyone. The cosmetic or dermatological formulation must thus be strictly performed for a particular need or needs of the skin. In the application WO-0191600, a process for the production of customized compositions is described, with the aid of a prior diagnosis of the skin of a patient, an apparatus for mixing selected products and the provision of of this mixture. However, the technical embodiments of the cosmetic compositions are not explained, such as the chemical nature of the components. Patent FR-2902995 describes a cosmetic or dermatological composition in the form of an emulsion. The emulsion is made extemporaneously by mixing a pulverulent phase composed of an oil and a porous solid with a generally aqueous hydrophilic phase. The problem with this composition is that it can contain only a limited number of active ingredients. Indeed, the active ingredient must either be solubilized in the hydrophilic phase, which limits its conditioning because of the risk of degradation and bacterial growth, or be integrated into the pulverulent phase which can cause problems of stability, homogenization or formulation of this powdery phase. In addition, the pulverulent phase and the hydrophilic phase must be adapted in order to carry out the emulsion extemporaneously, which limits the number of usable active ingredients. Finally, the cosmetic or dermatological composition according to the patent FR-2902995 does not make it possible to adjust extemporaneously the quantity or the nature of the active principles, in particular when these active ingredients must be incorporated in the process of manufacturing the powdery phase. A so-called fresh cosmetic composition has appeared, consisting of mixing active ingredients at the last minute to preserve their use on the skin, thanks to the improvement of preservation processes (dehydrated products) such as double-compartment packaging. A ready-made formula can not respond appropriately to the evolving needs of the skin. The current compositions, which contain a mixture of assets previously established and impossible to modify, do not allow any flexibility of use. There is still no custom made cosmetic composition, prepared extemporaneously, for integrating active ingredients in a manner that is both qualitatively flexible (nature of the skin problem), quantitative (degree of severity of the skin problem), and stable (stability of the cosmetic composition, in particular an emulsion and preservation of the active ingredient). The present invention aims to solve these problems by proposing an extemporaneous product comprising, on the one hand, a universal base and, on the other hand, one or more active principles chosen by means of a personalized diagnosis of the skin of the patient. The subject of the invention is therefore an extemporaneous product for cosmetic and / or dermatological treatments comprising at least: one or more active ingredients acceptable in the field of cosmetic and / or dermatological skin care, in pulverulent or liquid form, and a universal base comprising: at least one oil having a mass content of α-linolenic acid of greater than 15% and an omega-6 mass ratio of omega-3 of less than or equal to 5% of water; glycerin, one or more emulsifiers, at least one other alcohol than glycerine, acceptable in cosmetic and / or dermatological compositions, at least one biomimetic peptide of general formula AX-Gly-His-Lys-Y in which: A represents a hydrogen atom or a radical of a monocarboxylic acid of the general formula R-COOH wherein R represents an aliphatic radical comprising one to eleven carbon atoms, - X represents a single bond, lysine, arginine or ornithine, and Y represents a -OH or NH 2 group, said universal base being able to solubilize said active ingredient (s).
    [0002] According to one characteristic of the invention, the oil is present in the universal base in a mass concentration of between 5 and 25%, and preferably between 7.5 and 15%. According to another characteristic of the invention, the oil is chosen from the following oils: camelina oil, pumpkin seed oil, hemp seed oil, linseed oil and olive oil. perilla. According to yet another characteristic of the invention, the glycerol is present in the universal base in a mass concentration of between 1 and 20%, and preferably between 1 and 10%. According to yet another characteristic of the invention, the universal base comprises at least one of the emulsifiers whose INCI EU name is the following: sodium acrylate / sodium acryloyldimethyl taurate copolymer, polysorbate 80, xantham gum. According to yet another characteristic of the invention, the universal base comprises at least one or more emulsifiers with a total mass concentration of between 1 and 5%. According to yet another characteristic of the invention, the other alcohol is present in the universal base in a mass concentration of between 10 and 30%, and preferably between 15 and 25%. According to another characteristic of the invention, the other alcohol of the universal base is selected from the group consisting of ethanol, propanol, propanediol, propan-2-ol, propylene glycol, methylene glycol, or trimethylene glycol. According to yet another characteristic of the invention, the biomimetic peptide is present in the universal base in a concentration ranging from 1 to 20 ppm, preferably from 3 to 10 ppm. According to yet another characteristic of the invention, the universal base comprises at least one biomimetic peptide of formula H-Gly-His-Lys-OH. According to yet another characteristic of the invention, the universal base further comprises hyaluronic acid, preferably in a mass concentration of less than 5%. According to yet another feature of the invention, one or more active ingredients are selected from the group consisting of ferulic acid, phloretin, SOD, retinol, niacinamide, DMAE or dimethyl aminoethanol, resveratrol, genistein, phytic acid, kojic acid, glycolic acid, arbutin, azelaic acid, N-acetyl cysteine, tyrosine, alpha-lipoic acid, vitamin C, vitamin B5 , vitamin B3, zinc and magnesium gluconates, salicylic acid, rutin, aloe vera, and madecassosides. According to yet another characteristic of the invention, one or more active principles are chosen from the families of the group consisting of flavonoids, chalcones, zinc, calcium and magnesium salts of gluconic acid, vitamins and alpha and betahydroxy acids. Another subject of the invention relates to a kit for extemporaneous preparation of a cosmetic and / or dermatological composition using an extemporaneous product, characterized in that it consists of a first sealed package containing the universal base, and a second sealed package containing at least one active ingredient, the two packagings being able to be reversibly joined together and comprising means for joining their contents by a simple manipulation or pressure. A first advantage of the invention lies in the possibility of preparing a large number of extemporaneous cosmetic and / or dermatological formulations.
    [0003] Another advantage of the invention lies in the stability over time of the universal base on the one hand and the active ingredients on the other hand. Yet another advantage of the invention lies in the simplicity of preparing cosmetic and / or dermatological compositions extemporaneously. Yet another advantage of the invention lies in the adjustment of the nature and amount of each active ingredient according to the type of physiological affection or need of the skin and the importance of this affection or need. . Yet another advantage of the invention lies in the possibility of simply obtaining extemporaneous preparations, that is to say, made to measure by a pharmacist, an aesthetic doctor or a dermatologist, possibly according to a recommendation and / or or prescription prescribed by a doctor, for the treatment or skin care of a given patient, including pathology (eg acne) and / or need (eg, sagging skin, wrinkles and fine lines), and therapeutic properties (eg depigmentation). Yet another advantage of the invention lies in the selection by the pharmacist, the doctor or the dermatologist of the treatment of the skin according to the actual cutaneous dysfunction. Yet another advantage of the invention lies in the wide spectrum of skin disorders treated or cutaneous requirements filled by the presence, in extemporaneously prepared skin compositions, of biomimetic peptides, a biological action and on the other hand, traditional active principles with a dynamic action. Other characteristics, details and advantages of the invention will be better understood on reading the additional description given by way of example in relation to drawings in which: FIG. 1 represents a bottle containing the universal screwed base with a plug containing an active principle, and - Figure 2 shows a bottle containing the universal base screwed with a plug pouring an active ingredient into the bottle. The invention is intended for the use of the extemporaneous product by the pharmacists, dermatologists, general practitioners or aesthetic pharmacists for the preparation of cosmetic and / or dermatological compositions prepared extemporaneously according to the dermatological and / or cosmetic need of the patient. The applicants have thus discovered, after long and patient research, an extemporaneous product comprising on the one hand a universal base and on the other hand one or more active ingredients. By extemporaneous product is meant a product in two parts, comprising on the one hand a universal base and on the other hand one or more active ingredients, this extemporaneous product being intended for the preparation of a cosmetic and / or dermatological composition of extemporaneous way. By universal base is meant a composition capable of solubilizing a large number of active ingredients and comprising at least one oil rich in polyunsaturated essential fatty acids and more particularly in omega-3, water, glycerol, at least one alcohol other than glycerin acceptable in cosmetics and / or dermatology, one or more emulsifying agents, and at least one biomimetic peptide. The universal base also has a high stability over time which facilitates its preservation to prepare a composition extemporaneously. The universal base may especially be an emulsion. This universal base is capable of solubilizing the various active ingredients while remaining stable for at least 30 days, which is twice the prescribed duration of use of the extemporaneously prepared composition which is therefore 15 days. By oil rich in polyunsaturated essential fatty acids and more particularly in omega-3 is meant an oil which has a high mass percentage of linolenic acid, that is to say at least 15%, and an omega-3 mass ratio. The oil described above allows not only to solubilize certain active ingredients, but also has a recognized beneficial action on the skin. favoring the restoration of the hydrolipidic film and the production, under certain conditions, of omega-3 cutaneous. In the context of the invention, the oil present in the composition may in particular be one of the following oils: camelina oil, also known by the name of camelina seed oil, pumpkin seed oil, lemon oil, hemp oil, linseed oil and perilla oil. All of these oils have the characteristics previously described. In the context of the invention, the water present in the universal base is water usually used in cosmetics or dermatology. It may especially be distilled water, demineralized water or, on the contrary, mineral water, thermal water, etc. Glycerol, or glycerol, of formula HOH2C-CHOH-CH2OH, is a polyol well known in cosmetics, allowing in particular to overcome certain lipid functions defective in the skin. Glycerin allows, among other things, better hydration, the restoration of natural defenses, the regulation of desquamation, the improvement of the elasticity of the skin and the repair of the epidermis.
    [0004] By other alcohol is meant any alcohol, with the exception of glycerine, commonly used in cosmetics and / or dermatology, such as ethanol, propanol, propanediol, propan-2-ol, propylene glycol, methylene glycol, trimethylene glycol, etc. By emulsifying agents is meant any emulsion-promoting compounds, such as surfactants, anti-caking agents, stabilizers, etc. These include (INCI EU names): sodium acrylate / sodium acryloyldimethyl taurate copolymer, polysorbate 80 and xanthan gum. These three compounds can also be introduced together into the universal base. The universal base may be for example a gel or a complex emulsion (triple emulsion, nanoemulsion, microencapsulation, etc.). In the context of the invention, the biomimetic peptides used are of the general formula A-X-Gly-His-Lys-Y. A represents a hydrogen atom or a radical of a monocarboxylic acid of the general formula R-COOH in which R 20 represents an aliphatic radical comprising one to eleven carbon atoms. X represents a single bond or lysine, arginine or ornithine. Y is -OH or NH2. Finally, Gly, His and Lys respectively represent glycine, histidine and lysine. The peptides are typically present in the universal base in amounts of 1 to 20 ppm, preferably 3 to 10 ppm. One of the preferred peptides is that of formula: H-Gly-HisLys-OH. One can optionally combine in the universal base several peptides, such as those marketed by companies such as for example Lucas Meyer, Unipex, Mibelle, Caregen. The trade names of the peptides marketed by these companies are, for example, Kollaren®, Thymulen, O, Melitane®, ECM ProtectO, B-White, etc. This makes it possible to cover a very wide range of cutaneous needs. Biomimetic peptides are powerful active ingredients used in cosmetics and dermatology. They precisely stimulate certain dysfunctional skin functions. Thus, the universal base is in itself active cosmetically and / or dermatologically. Thus, it is possible to prepare various universal bases each comprising one or more biomimetic peptides without disturbing the stability of the universal base. Optionally, the universal base may further comprise hyaluronic acid, for its lubricating and moisturizing effect, at a concentration preferably of less than 5% by weight. Universal bases in themselves exhibit cutaneous activity thanks to biomimetic peptides. They can therefore target various pathologies and skin dysfunctions. It is thus possible to prepare universal bases for all the pathologies, dysfunctions / skin needs encountered by the professionals of the field, and then to reinforce, potentiate or complete their effects with various active principles, in particular those mentioned above. The universal base makes it possible in particular to solubilize a very large number of active principles and families of active principles. Among the active ingredients which can be used, mention may be made in particular of: ferulic acid, phloretin or dihydro-chalcone, SOD, retinol, niacinamide, DMAE or dimethylaminoethanol, resveratrol, - genistein, - phytic acid, - kojic acid, - glycolic acid, - arbutin or β-glucoside of hydroquinone, - azelaic acid, - N-acetyl cysteine, - the tyrosine, - alpha-lipoic acid, - vitamin C, - zinc and magnesium gluconates, - salicylic acid, - quercetin rutin or di-glycoside, - vitamin B3, - aloe vera - madecassosides, - vitamin B5.
    [0005] Among the active agent families that may be used in the invention, mention may be made in particular of: amino acids, flavonoids, chalcones, zinc, calcium and magnesium salts of gluconic acid, vitamins, - alpha and beta-hydroxy acids (ARA - BHA). - aloe vera 20 - other plant extracts The active ingredients used in the invention have a high degree of purity and can be pulverulent or liquid. They can optionally be dispersed in galenic products such as anti-caking, fluidifying excipients, etc. The preparation of the cosmetic and / or dermatological compositions in an extemporaneous manner can be carried out in a simple manner by providing a kit, for example consisting of a cap and a bottle, both packages being sealed before use. The stopper contains one or more active ingredients. The bottle contains the universal base. The cap is adapted to be screwed onto the bottle. When the cap is screwed onto the bottle, it is sufficient to exert pressure on the top of the stopper to release the active ingredient by rupture of a membrane and pour it into the universal base. The solubilization of the active ingredient in the universal base is by simple agitation, optionally with a suitable apparatus. FIG. 1 represents a bottle 1 containing the universal base 3 and an upper part 10 provided with a thread 2 on its outer edges, this bottle 1 being screwed to a hollow plug 4 containing the active ingredient 8. The plug 4 has a thread 6 inside complementary tapping 2 of the bottle 1 and a membrane 5a in a closed position, ensuring the tightness of the cap.
    [0006] When the upper part 9 of the cap 4 is pressed, the active ingredient 8 is poured into the bottle 8 and thus mixes with the universal base 3. FIG. 2 represents the same bottle 1 screwed with a stopper 4 as in FIG. 1 but after pressing on the upper part / 9 of the plug 4. The membrane 5b is then broken by an element 7 of the lower part 11 of the plug, which allows the active ingredient 8 to pour into the bottle 1 and mix at the universal base 3. The same active ingredient can be added in several times to increase the effect of the cosmetic and / or dermatological composition prepared extemporaneously, or else to choose several complementary active principles, or else to choose active principles having different effects. Several dozen predetermined stoppers each containing one or more active ingredients at a defined dose can thus be made available to the pharmacist or doctor. In order that the amounts of active ingredients introduced into the stopper are homogeneous, the pure active ingredients may be dispersed in a powdery ingredient such as starch, dextran, aerosil, etc. This ingredient can possibly be liquid. The active ingredients are present in the cap in their purest form and in an optimal concentration. The concentration varies according to the active ingredient and is in accordance with the legislation in force. The assistance of a professional such as a pharmacist, a cosmetic doctor or a dermatologist may be necessary. This assistance is indeed recommended to precisely perform the diagnosis of the skin, then the choice and dosage of one or more active ingredients, the homogenization of the mixture and the advice of use to the consumer (eg dosage). The professional can optionally perform the diagnosis of the patient's skin using one of the following devices: Cornéomètre®, Cutomètre®, Mobile Skin Scope MSS, Quantirides®, Sebumeter (), Mexameter0, etc. All concentrations expressed as percentages in the present application are in percent by weight. In the general scope of the invention, the following skin disorders can be particularly treated: acne, oily skin, sensitive skin, redness, pruritus, psoriasis, scarring, accelerated and / or chronological aging, peeling, skin inflammation, effects UV radiation, blackheads, excess sebum, enlarged pores, pigment spots, hyperpigmentation, irritations, rosacea, atopic dermatitis, bacterial or viral infections, loss of firmness, lines and wrinkles, etc. The application on the skin of cosmetic and / or dermatological preparations is preferably carried out dropwise and then by hand. A number of cosmetic and / or dermatological compositions having the following formulations were made extemporaneously. The concentrations are always mass. The percentages of the commercial peptides in the universal base do not correspond to the percentage of the pure peptides, because "commercial peptides" is understood as the formulations in which the different peptides are sold, the final concentration of the pure peptide always being between 1 and 20 ppm. Example 1 To illustrate an exemplary embodiment of the invention, a cosmetic composition containing the B-White biomimetic peptide is prepared to treat a depigmenting effect, and a plug containing 3% arbutin active ingredient is added.
    [0007] Formula 1% by weight Camelina oil 12 Ethanol 24 Glycerin 2.5 Emulsifier 3 Water QSP Commercial peptide: B-White 5 Active ingredient 3 Example 2 To a bottle containing 13 ml of the composition according to Example 1 is added, for a slight disorder of the pigmentation of a patient, an active ingredient using a plug containing 700 mg of azelaic acid (ie about 5.4% / 5 azelaic acid for the total composition). EXAMPLE 3 To a vial containing the composition according to Example 2 is added, for a major hyperpigmentation disorder of the skin of a patient, an additional active ingredient using a plug containing 390 mg of arbutin. . Arbutin is then added twice to prepare the composition extemporaneously. EXAMPLE 4 Formula 4% by weight Camelina oil Ethanol Glycerin 2 Emulsifier 1.75 Water QSP Commercial peptides 0.003 Kollaren GL 5000PPM Melitane GL 1000PPM 35 Thymulen 47 GL 1000PPM, ECM Protect GL 1000PPM Active ingredient 1 Example 5 Formula 5% mass Camelina oil 8 Ethanol 12 Glycerin 1,2 Emulsifier 4 Water QSP Peptides Kollaren GL 5000PPM 0,001 Active ingredient: kojic acid 2 Example 6 Formula 6% by weight Camelina oil 6 Ethanol 16/5 Glycerin 2 Emulsifier 2 Water QSP Peptides Melitane GL 1000PPM 0.001 Hyaluronic acid 0.3 Active ingredient: Vitamin E5 5.5 The tests conducted from the compositions of Examples 1 to 6 gave excellent results in the treatment of various skin conditions or in response to allergies. different skin needs. They have excellent stability and storage at room temperature for 30 days did not lead to any degradation of these compositions. In addition, no loss of effectiveness was found. Compositions 1 to 6 were each made in the same way by substituting camelina oil with the following oils: pumpkin seed oil, hemp seed oil, linseed oil and coconut oil. In the same way, each of the compositions 1 to 6 was carried out by replacing the ethanol with the following alcohols: ethanol, propanol, propanediol, propan-2-ol, propylene glycol, methylene glycol , or trimethylene glycol.
    [0008] Stability, effectiveness and degradation tests of the modified compositions gave the same results as those obtained with camelina oil. It is the same when the ethanol is replaced by other alcohols mentioned above.
    权利要求:
    Claims (14)
    [0001]
    REVENDICATIONS1. Extemporaneous product for cosmetic and / or dermatological treatments comprising at least: one or more active ingredients acceptable in the field of cosmetic and / or dermatological skin care, in pulverulent or liquid form, and a universal base comprising: at least an oil having a mass content of α-linolenic acid greater than 15% and an omega-6 mass ratio on omega-3 of less than or equal to 5%, water, glycerine, one or more emulsifiers, at least one other alcohol than glycerin, acceptable in cosmetic and / or dermatological compositions, at least one biomimetic peptide of general formula AX-Gly-His-Lys-Y in which: A represents an atom of hydrogen or a radical of a monocarboxylic acid of the general formula R-COOH wherein R represents an aliphatic radical comprising one to eleven carbon atoms, - X represents a single bond, lysine, arginine or ornithine, and Y represents a group -OH or NH 2, said universal base being able to solubilize said active ingredient (s).
    [0002]
    2. Extemporaneous product according to claim 1, characterized in that the oil is present in the universal base in a mass concentration of between 5 and 25%, and preferably between 7.5 and 15%.
    [0003]
    3. An extemporaneous product according to claim 1 or claim 2, characterized in that the oil is selected from the following oils: camelina oil, pumpkin seed oil, hemp oil, coconut oil flax and perilla oil.
    [0004]
    4. extemporaneous product according to one of the preceding claims, characterized in that the glycerine is present in the universal base in a mass concentration of between 1 and 20%, and preferably between 1 and 10%.
    [0005]
    5. extemporaneous product according to one of the preceding claims, characterized in that the universal base comprises at least one of the emulsifiers whose INCI UE name is: sodium acrylate / sodium acryloyldimethyl taurate copolymer, polysorbate 80, xantham gum.
    [0006]
    6. extemporaneous product according to one of the preceding claims, characterized in that the universal base 10 comprises at least one or more emulsifiers in a total mass concentration of between 1 and 5%.
    [0007]
    7. extemporaneous product according to one of the preceding claims, characterized in that the other alcohol is present in the universal base in a mass concentration / 5 between 10 and 30%, and preferably between 15 and 25%.
    [0008]
    8. extemporaneous product according to one of the preceding claims, characterized in that the other alcohol of the universal base is selected from the group consisting of ethanol, propanol, propanediol, propan-2-ol, the propylene glycol, methylene glycol, or trimethylene glycol.
    [0009]
    9. extemporaneous product according to one of the preceding claims, characterized in that the biomimetic peptide is present in the universal base in a concentration ranging from 1 to 20 ppm, preferably from 3 to 10 ppm.
    [0010]
    10. extemporaneous product according to one of the preceding claims, characterized in that the universal base comprises at least one biomimetic peptide of formula H-GlyHis-Lys-OH. 30
    [0011]
    11. extemporaneous product according to one of the preceding claims, characterized in that the universal base further comprises hyaluronic acid, preferably in a mass concentration of less than 5%.
    [0012]
    12. extemporaneous product according to one of the preceding claims, characterized in that one or more active ingredients are selected from the group consisting of ferulic acid, phloretin, SOD, retinol, niacinamide, DMAE or dimethyl aminoethanol, resveratrol, lagenistein, phytic acid, kojic acid, glycolic acid, arbutin, azelaic acid, N-acetyl cysteine, tyrosine, alpha-lipoic acid, vitamin C, vitamin B5, vitamin B3, zinc and magnesium gluconates, salicylic acid, rutin, aloe vera and madecassosides.
    [0013]
    13. extemporaneous product according to one of the preceding claims, characterized in that one or more active ingredients are selected from the families of the group consisting of flavonoids, chalcones, zinc salts, calcium and magnesium of the gluconic acid, vitamins and alpha and beta-hydroxy acids.
    [0014]
    14. Extemporaneous preparation kit of a cosmetic and / or dermatological composition using an extemporaneous product according to one of the preceding claims, characterized in that it consists of a first sealed package containing the universal base, and a second sealed package containing at least one active ingredient, the two packages being reversibly joined together and comprising means for joining their contents by simple manipulation or pressure.
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    BR112016026660B1|2021-05-18|
    ES2825653T3|2021-05-17|
    KR20170015334A|2017-02-08|
    PT3145480T|2020-10-21|
    EP3145480A1|2017-03-29|
    DK3145480T3|2020-10-19|
    AU2020203928A1|2020-07-02|
    AU2015261352A1|2016-12-22|
    CA2948926A1|2015-11-19|
    EP3145480B1|2020-07-15|
    US20210393507A1|2021-12-23|
    FR3020946B1|2017-09-22|
    WO2015173481A1|2015-11-19|
    MX2016014906A|2017-12-15|
    CN106572966A|2017-04-19|
    PL3145480T3|2021-04-06|
    AU2015261352B2|2020-07-09|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    EP1027878A1|1999-02-05|2000-08-16|L'oreal|Cosmetic and/or dermatological composition in the form of an oil-in-water emulsion formed by lipid vesicles dispersed in an aqueous phase containing at least one active hydrophilic acid|
    FR2906463A1|2006-09-28|2008-04-04|Oreal|Composition, to prepare cosmetic set to carry out superficial peeling e.g. to reduce visible and/or tactile irregularities of skin e.g. wrinkles and dull and/or uneven complexion, comprises glycosaminoglycan and desquamating agent|
    FR2913602A1|2007-03-15|2008-09-19|Michel Yvan Hocquaux|Composition, useful e.g. for care of skin damaged by aesthetic treatment, cosmetic/therapeutic such as surgical interventions, laser treatment, dermabrasions and peelings, comprises peptide associated with oil having alpha-linolenic acid|
    AU6501601A|2000-05-31|2001-12-11|Procter & Gamble|Methods and system for providing personalized preparations|
    CA2587098C|2004-11-08|2015-12-29|Julie R. Bartholomew|Automated customized cosmetic dispenser|
    FR2902995B1|2006-06-29|2008-09-12|Lessonia|EXTREMELY EMULSIONABLE PREPARATION BASED ON ACTIVE INGREDIENTS, FOR COSMETOLOGY, DERMATOLOGY OR SPA|RU2689156C1|2018-08-27|2019-05-24|Индивидуальный предприниматель Талагаева Елена Владимировна|Active additive to perfume and cosmetic products|
    KR102181581B1|2018-11-15|2020-11-20|주식회사 마린테크노|customized cosmetics according to constitution and skin type, Providing method cosmetics using the same|
    CN109893462B|2019-03-13|2022-01-11|伯德创研生物科技有限公司|Mild oil-controlling blackhead-removing spray and preparation method thereof|
    FR3101251A1|2019-09-26|2021-04-02|Sandrine Sebban|Formulation for topical application to skin or mucous membranes|
    法律状态:
    2015-05-28| PLFP| Fee payment|Year of fee payment: 2 |
    2015-11-20| PLSC| Publication of the preliminary search report|Effective date: 20151120 |
    2016-05-31| PLFP| Fee payment|Year of fee payment: 3 |
    2017-05-29| PLFP| Fee payment|Year of fee payment: 4 |
    2018-05-31| PLFP| Fee payment|Year of fee payment: 5 |
    2019-05-30| PLFP| Fee payment|Year of fee payment: 6 |
    2020-05-29| PLFP| Fee payment|Year of fee payment: 7 |
    2021-05-31| PLFP| Fee payment|Year of fee payment: 8 |
    优先权:
    申请号 | 申请日 | 专利标题
    FR1401067A|FR3020946B1|2014-05-13|2014-05-13|NEW EXTERNAL COSMETIC AND / OR DERMATOLOGICAL PREPARATIONS|FR1401067A| FR3020946B1|2014-05-13|2014-05-13|NEW EXTERNAL COSMETIC AND / OR DERMATOLOGICAL PREPARATIONS|
    AU2015261352A| AU2015261352B2|2014-05-13|2015-05-13|Extemporaneous cosmetic and/or dermatological preparations|
    MX2016014906A| MX2016014906A|2014-05-13|2015-05-13|Extemporaneous cosmetic and/or dermatological preparations.|
    BR112016026660-9A| BR112016026660B1|2014-05-13|2015-05-13|extemporaneous product for cosmetic and/or dermatological care, and extemporaneous preparation kit of a cosmetic and/or dermatological composition|
    EP15732763.6A| EP3145480B1|2014-05-13|2015-05-13|Extemporaneous cosmetic and/or dermatologic compositions|
    CN201580037614.XA| CN106572966A|2014-05-13|2015-05-13|Extemporaneous cosmetic and/or dermatological preparations|
    ES15732763T| ES2825653T3|2014-05-13|2015-05-13|Extemporaneous cosmetic and / or dermatological preparations|
    PT157327636T| PT3145480T|2014-05-13|2015-05-13|Extemporaneous cosmetic and/or dermatological preparations|
    DK15732763.6T| DK3145480T3|2014-05-13|2015-05-13|Specially made cosmetic and / or dermatological products|
    PL15732763T| PL3145480T3|2014-05-13|2015-05-13|Extemporaneous cosmetic and/or dermatologic compositions|
    KR1020167034916A| KR20170015334A|2014-05-13|2015-05-13|Extemporaneous cosmetic and/or dermatological preparations|
    US15/311,066| US20170095415A1|2014-05-13|2015-05-13|Extemporaneous cosmetic and/or dermatological preparations|
    PCT/FR2015/000097| WO2015173481A1|2014-05-13|2015-05-13|Extemporaneous cosmetic and/or dermatological preparations|
    CA2948926A| CA2948926A1|2014-05-13|2015-05-13|Extemporaneous cosmetic and/or dermatological preparations|
    AU2020203928A| AU2020203928A1|2014-05-13|2020-06-12|New extemporaneous cosmetic and/or dermatological preparations|
    US17/349,315| US20210393507A1|2014-05-13|2021-06-16|Extemporaneous cosmetic and/or dermatological preparations|
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